The U.S. military on Tuesday carried out a lethal strike on a vessel in the eastern Pacific that it said was involved in drug trafficking, killing five people it identified as "narco-terrorists," according to U.S. Southern Command (SOUTHCOM).

"On October 27, under the direction of SOUTHCOM, Joint Task Force Western Hemisphere executed a lethal, kinetic strike on a go-fast vessel operating along established narco-trafficking routes in the Eastern Pacific," SOUTHCOM said in a statement.

"Confirmed intelligence revealed the vessel's active involvement in narco-trafficking," the statement continued.

SOUTHCOM said five people it described as narco-terrorists were killed during the operation.

US FORCES OBLITERATE SUSPECTED 'NARCO-TERRORIST' VESSEL IN LETHAL EASTERN PACIFIC STRIKE, KILLING 3

U.S. Southern Command released footage of a military strike on a suspected drug-trafficking vessel in the eastern Pacific on Oct. 27, 2026. (U.S. Southern Command)

Tuesday's strike was the latest in the Trump administration's monthslong campaign targeting suspected cartel vessels, which has now resulted in at least 240 deaths from more than 70 strikes, according to The Associated Press.

Video of Tuesday's operation released by SOUTHCOM shows a vessel in the water before it erupts into a massive fireball.

SOUTHCOM did not specify where the strike occurred beyond identifying the eastern Pacific and saying the vessel was operating along established drug-trafficking routes.

US KILLS TWO 'NARCO-TERRORISTS' IN STRIKE 2 MONTHS SINCE LAST ANNOUNCED ANTI-'NARCO-TRAFFICKING' ATTACK

A vessel erupts into flames after being targeted by a U.S. military strike in the eastern Pacific that killed five people, according to SOUTHCOM. (U.S. Southern Command)

Throughout its campaign targeting suspected drug-trafficking networks, the military has released videos and statements describing those aboard the targeted vessels as "narco-terrorists" or alleging links to designated terrorist organizations. However, it has generally not identified those killed or provided evidence that the vessels were carrying narcotics.

The strikes have generated scrutiny from lawmakers, legal experts and human rights groups who have questioned the legal basis for using lethal military force against suspected traffickers outside a traditional battlefield.

SOUTHCOM's continued operations in Latin America and the Caribbean come after Secretary of State Marco Rubio said last month that the U.S. was increasingly seeking to conduct counter-narcotics operations in cooperation with regional allies and in accordance with their laws.

Rubio told reporters that while the U.S. has "the capacity to act unilaterally," it would rather work with its allies because that is "the most effective way to do it."

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Secretary of State Marco Rubio has said the United States prefers to work with regional allies on counter-narcotics operations while maintaining the ability to act unilaterally. (ANDREW CABALLERO-REYNOLDS/AFP via Getty Images)

Rubio also said the U.S. military would "still blow up ships if need be" and that decisions would be made on "a strike-by-strike or operation-by-operation" basis.

In recent months, SOUTHCOM has also released several videos showing military personnel intercepting and boarding vessels it said were involved in narco-trafficking before removing their crews and sinking the boats.

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The Associated Press contributed to this report.